082 Comparing psychometric properties of EQ-5D-3L and EQ-5D-5L in atopic dermatitis

Generic health-related quality of life (HRQoL) instruments, such as EQ-5D, are important tools in economic evaluations for measuring disease burden and generating quality-adjusted years (QALYs). Our goal was to compare measurement properties two versions this instrument, the EQ-5D-3L (3L) EQ-5D-5L (5L) atopic dermatitis (AD). We conducted a multicentre cross-sectional survey Hungary, involving 218 adult AD patients with mild severe disease. The 3L 5L demonstrated good agreement an intraclass correlation coefficient 0.815 (95%CI 0.758-0.859, p<0.001). ceiling effect reduced by 4.6-11.5% mobility, self-care, usual activities, pain/discomfort dimensions compared 3L. In 5L, 84 unique health state profiles occurred, while only 33 Average relative informativity higher version (Shannon’s evenness index: 0.64 vs. 0.59) it better convergent validity EQ VAS, DLQI, Skindex-16. Both were similarly able distinguish among groups based on severity skin-specific HRQoL moderate or large size (η2=0.083-0.489). To sum up, performed than terms effect, informativity, validity, thus we recommend use outcomes calculating QALYs AD.